Fox Chase researcher Jeffrey R. Peterson, Ph.D. and his colleagues describe a new way in chemical genetics to swiftly find the proteins targeted by small molecule inhibitors during high-throughput screening (HTS) experiments. This new finding highlighted on the April cover of Chemistry & Biology offers a critical solution to a common stumbling block in this booming field of drug discovery.
HTS allows researchers to test thousands of small drug-like molecules at once for a specific biological activity, such as inhibiting the cell movements that allow cancer cells to spread in the body. Screening for potential new drug compounds in complex systems differs from the traditional drug discovery approach, which begins with one particular protein of interest and tries to find inhibitors for that specific target.
Read more at Science Daily.
Photo Credit: Chemistry & Biology
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