You will remember that the arthritis drug Celebrex has been linked with heart attack.
Just very recently, two major long-term clinical trials has been presented at the American Association for Cancer Research meeting showing that the Pfizer's COX-2 inhibitor, Celebrex (celecoxib), helps stop the growth of pre-cancerous polyps (adenomas) that can lead to colon cancer.
One out of five adenomas in the colon develops into colon cancer if not removed. The trials were designed to test whether Celebrex, a COX-2 inhibitor, could help prevent the pre-cancerous polyps by blocking the COX-2 enzyme that has been shown to be a possible factor in the formation of pre-cancerous polyps (benign tumors). Pre-cancerous polyps, if left undetected and untreated, can grow into full-blown colon cancer and spread.
"Importantly, both trials showed the largest benefit in people who had the most advanced polyps -- which have a higher risk of developing into cancer," said Dr. Joseph Feczko, chief medical officer at Pfizer. "Colorectal cancer takes years to develop and frequently starts with an adenomatous polyp that transforms over many years into cancer. These trials reflect the growing focus on the use of pharmaceutical medicines in cancer prevention."
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