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May23
Vertex Pharmaceuticals' VX-950 Against Hepatitis C Shows Favorable Results From Phase II Clinical Studies
Vertex Pharmaceuticals Incorporated announced that, in Phase II clinical studies, in combination with pegylated interferon alfa-2a (Pegasys®; peg-IFN) and ribavirin (RBV), the company's lead candidate against hepatitis C virus (HCV), VX-950 reduced HCV RNA to undetectable levels in 100% of the patients, with 92% remaining undetectable HCV RNA through 12 weeks of follow-on therapy. VX-950 is an inhibitor of HCV protease, an enzyme essential for viral replication.
"With the combination of VX-950, pegylated interferon and ribavirin, we observed unprecedented antiviral activity, with all 12 genotype 1 patients reaching viral levels below the limits of detection at the end of dosing at 28 days," said Eric Lawitz, M.D., of Alamo Medical Research in San Antonio, the investigator presenting the study results. "In addition, no serious adverse events were reported, and those adverse events that were reported are similar to those observed in previous studies of pegylated interferon and ribavirin. These results are highly encouraging for the initiation of future VX-950 studies that seek to evaluate the potential for viral eradication with short duration therapy."
The results of the trial were announced during the ongoing Digestive Disease Week (DDW). More info about VX-950 and the study design from Vertex Pharmaceuticals press release.

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