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Jun15
Phase IIb Clinical Trials Show Lorcaserin Hydrochloride Cause Significant Weight Loss in Obese Patients
Gloria Gamat June 15, 2006
Know More: Patents and Clinical Trials
Arena Pharmaceuticals, Inc.'s drug candidate for obesity, lorcaserin hydrochloride (formerly APD356) demonstrated favorable Phase IIb clinical trial results. Compared to placebo, patients treated with lorcaserin showed highly statistically significant average weight loss and reductions in other physical measures, including body mass index (BMI) and waist and hip circumference.
"Discovered through Arena's proprietary platform, lorcaserin is a highly selective compound which works on a specific serotonin receptor located in the hypothalamus, an area of the brain known to impact satiety and influence metabolic rate," stated Jack Lief, Arena's President and CEO. "Based on the strength of these data, we are currently in discussions with the FDA about initiating a Phase 3 trial of lorcaserin in obese patients later this year."
The results of the trials were presented during the recently concluded 66th Annual Scientific Sessions of the American Diabetes Association. Details of the study design and results were included in Arena's press release.

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