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Oct17
Neuren's NNZ-2591, Proved Effective At Memory Loss Reversal
Neuren Pharmaceuticals Ltd (ASX: NEU)’s lead candidate from its diketopiperazine (DKP) family, NNZ-2591, demonstrated positive preclinical effects of improved learning and memory after oral dosing.
Memory was improved to pre-injury levels (100%), a statistically significant effect (p<0.03).

The following being the key points obtained:

  • NNZ-2591 has successfully reversed experimental memory loss, a common outcome associated with dementia and with many Parkinson's disease patients
  • This improvement was seen in both ordinary (non-aged) animals with induced memory loss and older (aged) animals, the latter indicated the reversal of aged related memory loss as well
  • Previous preclinical data for oral NNZ-2591 has shown improvement in the motor effects associated with Parkinson's
  • NNZ-2591 now has preclinical evidence that it reverses both the motor effect and the memory loss effect associated with Parkinson's disease
  • There is currently only one drug approved for Parkinson disease dementia but none approved that treats both the motor and the dementia effects
  • Neuren intends to accelerate development of NNZ-2591 as a clinical candidate for treatment of Parkinson's disease dementia
  • These preclinical data suggests that NNZ-2591 has the capacity to improve learning and memory processes after short-term treatment, extending the potential application of NNZ-2591 as a treatment for dementias such as those associated with over 50% of Parkinson's disease patients.

    Find more details from Neuren’s press release (a pdf file).

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