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Oct29
NicOx’s Naproxcinod Sucessfully Passed Osteoarthritis Phase 3 Trial
Gloria Gamat October 29, 2006
Know More: Patents and Clinical Trials
NicOx S.A. (EPA: COX) recently announced the successful top-line results from a phase 3 trial of naproxcinod (HCT 3012) in patients with osteoarthritis of the knee (the 301 study).

Naproxcinod is the first compound in the COX-Inhibiting Nitric Oxide-Donating (CINOD) class, which NicOx S/A aims to establish as the drug-of-choice for the treatment of osteoarthritis.

According to Thomas J. Schnitzer, MD, PhD, Professor and Assistant Dean for Clinical Research at Northwestern University and Principal Investigator on the trial:
"The positive outcome of this pivotal trial for naproxcinod is an important step towards making this an efficacious and potentially safer treatment option for osteoarthritis patients.

The blood pressure data showing a clear improvement against naproxen and from baseline is also extremely encouraging, in the light of the considerable need for a non-steroidal anti-inflammatory drug with an improved blood pressure profile."
Compared to placebo, the two naproxcinod doses (375 mg bid and 750 mg bid) proved to be superior in treating the signs and symptoms of osteoarthritis.

Find more details of the clinical study results from the press release (a pdf file).

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