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Nov21
Pharmacyclics’ Xcytrin® Showed Positive Phase III Trials in Lung Cancer Brain Metastasis
Pooled results from Pharmacyclics, Inc. (Nasdaq: PCYC)’s two randomized Phase 3 clinical trials indicated that Xcytrin® (motexafin gadolinium) Injection combined with whole brain radiation therapy (WBRT) significantly prolonged time to neurologic progression in non-small cell lung cancer (NSCLC) patients with brain metastases.

Such findings were presented at the recently held Society for Neuro-Oncology's 11th Annual Meeting in Orlando, FL.

lung_cancer_with_brain_metastases.jpgAccording to William R. Shapiro, M.D., chief of the Neuro-Oncology Division of Neurology at the Barrow Neurological Institute, and presenter of the pooled Phase 3 results:

"These data demonstrate that Xcytrin, used in combination with whole brain radiation therapy, may significantly improve neurologic outcomes in patients with brain metastases from non-small cell lung cancer.”

These two large studies both used an innovative and clinically meaningful endpoint and reveal consistent benefit in this patient population."

Xcytrin® is Pharmacyclics’ lead anti-cancer agent with a novelly-designed to selectively concentrate in tumors and induce apoptosis (programmed cell death). Xcytrin®, a redox-active drug, has been shown to disrupt redox-dependent pathways in cells and inhibit oxidative stress related proteins: the multifunctional mode of action provides the opportunity to be used in a broad range of cancers.

Find more details from the press release.

[Photo Credit: Gamma Knife Center]


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« Target Hemoglobin Range in Most Anemic Chronic Kidney Disease Pre-Dialysis Patients Achieved With PROCRIT® (Epoetin alfa) Therapy Initiated Every Two Weeks | Main | BioCryst's Anti-Cancer Drug Fodosine™ Received Orphan Status In Europe »

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