GlaxoSmithKline plc (NYSE: GSK), ranked #3 in sales, invested 10% more in 2006 into research and development. The company experienced a huge hit when the FDA increased the warning label strength on the blockbuster drug Avandia. Add in the fact that several big drugs are nearing the end of their patent life and are facing generic competition and over all it wasn't a great year for GSK. However, the future looks bright for the company. The company has 33 drugs in Phase III development and expects to launch approximately 25 new drugs in the next two years.
Pending Approval:
Avandia + simvastatin - Type 2 diabetes
Hycamtin - small cell lung cancer, second-line therapy (oral formulation
Globorix - diptheria, tetanus, pertussis, hepatitis B, Haemophilus influenzae type b disease, Neisseria meningitis groups A & C disease prophylaxis
Infanrix-IPV/Kinrix - Diptheria, tetanus, pertussis and poliomyelitis prophylaxis
Flu pre-pandemic H5N1 - Pandemic influenza prophylaxis
Entereg/Entrareg - Post operative ileus Approvable
Gepirone ER - major depressive disorder, once-daily
Lamictal XR - Epilepsy
ReQuip XR - Restless legs syndrome
Trexima - Migraine
Phase III Pipeline:
Coreg CR† + ACE - hypertension
Avandamet XR - Type 2 diabetes
Avandia - Type 2 diabetes, Prevention of diabetes
Dacart - Uncomplicated malaria
Hycamtin - Ovarian cancer, first-line therapy
Ofatumumab - Chronic lymphocytic leukaemia (also rheumatoid arthritis), follicular lymphoma
Pazopanib - Renal cell cancer
Promacta/Revolade - Long-term idiopathic thrombocytopaenic purpura, short-term idiopathic thrombocytopaenic purpura
Rezonic/Zunrisa - chemotherapy-induced & postoperative nausea & vomiting (also depression & anxiety)
Tykerb/Tyverb ErbB-2 and EGFR - breast cancer, breast cancer brain metastases, breast cancer (first-line therapy), head & neck squamous cell carcinomas
Hib-MenCY-TT - Neisseria meningitis groups C & Y disease & Haemophilus influenzae type b disease prophylaxis
MenACWY-TT - Neisseria meningitis groups A, C, W and Y disease prophylaxis
Synflorix - Streptococcus pneumoniae & non-typable Haemophilus influenzae disease prophylaxis for children
MAGE-A3 - Non-small cell lung cancer
Avodart - Reduction in the risk of prostate cancer
Avodart + alpha blocker - benign prostatic hyperplasia
Belimumab - Systemic lupus erythematosus
Bosatria - Hypereosinophilic syndrome (also severe asthma & nasal polyposis)
Entereg/Entrareg - Opioid-induced bowel dysfunction
1838262 - Restless legs syndrome
Lamictal XR - Partial generalised tonic-clonic seizures, once-daily
Rosiglitazone XR - Alzheimer's disease
[Source: FierceBiotech]
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