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Jul23
Topamax (topiramate) May Cause Birth Defects

Only one month after Johnson & Johnson was required to put a black box warning on Regranex and a week after the U.S. Food and Drug Administration rejected a black box warning on epilepsy drugs, research has found that J&J's Topamax may increase the risk of birth defects.

The study, a small one of 203 patients, found a 14-fold increase in the risk of birth defects in patients taking the epilepsy drug Topamax. The risk was potentially even higher in patients that took Topamax with valproate (Depakote) or other epilepsy medications.

Topamax.jpgDue to the small size of the study, experts have stressed that more research is needed to confirm the possible birth defect link. Experts also stated that pregnant women who suffer from epilepsy should not stop taking there drug as the seizures without the medication can have an even greater damaging effect on the fetus. However patients taking the medication for the purpose of migraine relief and who are pregnant or contemplate getting pregnant are prompted to talk to the health care provider about a suitable alternative.

Epilepsy Drugs to get FDA Warning

Epilepsy Drugs Likely to Avoid FDA Black Box Warning

Alcoholics’ Quality of Life Improves with Topiramate

[Source:FiercePharma]

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4 Comments/Trackbacks




» Topamax Gets 6 Month Pediatric Exclusivity Extension from PharmaGazette
The U.S. Food and Drug Administration has granted a six month pediatric exclusivity to Ortho-McNeil-Janssen Pharmaceuticals for its drug Topamax for use in patients aged 1 to 24 months with partial onset seizures.The extension does not give the drug FD... [Read More]

My name is Maree Sneed and i would like to show you my personal experience with Topamax.

I am 27 years old. Have been on Topamax for 3 months now. Had severe debilitating migraines at least 2x a week. Had to stay in bed. I have a 7 year old. I was missing out on everything. Now I can get out of bed and get on with my day. I am down to maybe 1 migraine a month and it is functional not crippling.

I have experienced some of these side effects -
weight loss, no appetite, severe mood swings, emotional, yucky taste to cola, thirsty, thirsty, thirsty, extreme fatique

I hope this information will be useful to others,
Maree Sneed

It is also indicated in adults for the treatment of migraine headaches.

It is very useful and the postings are very interesting for more information you can check :
http://example.intc.com.tw

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